INTRANASAL DRUG DELIVERY
The nasal cavity is an important non-invasive drug delivery conduit for multiple diseases. Given the highly vascular surface of the nasal lining and its unique access to the blood brain barrier, intranasal drug delivery is an advantageous approach.1,2,3,4
- Non-invasive
- Rapid acting
- Easily self-administered
- Inexpensive
- Treatment of non-nasal diseases:
- Central Nervous System - through the blood brain barrier
- Migraine
- Neurodegenerative diseases (Alzheimer’s, Parkinson’s)
- Psychiatric disorders
- Seizure
- Systemic - through the highly vascular surface area
- Bleeding disorders
- Chronic pain
- Vaccines - rapid, inexpensive, self administration
- Central Nervous System - through the blood brain barrier
References:
1. Erdő F, et al. Evaluation of intranasal delivery route of drug administration for brain targeting. Brain Res Bull. 2018;143:155-170.
2. Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Adv. Drug Deliv. Rev. 2012;64:614-628.
3. Watelet JB,Van Cauwenberge P. Applied anatomy and physiology of the nose and paranasal sinuses. Allergy. 1998;54:14-25.
4. Lungare S, Bowen J, Badhan R. Development and evaluation of a novel intranasal spray for the delivery of amantadine J. Pharm. Sci. 2016:105;1209-1220.
